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Thursday, 29. Oct. 2015
Audio-only-Recording as MP3-File (smallest possible size):
- Audio.mp3 (ca.27 Mb)
Video-Recording for any system with MP4-support:
- Video.mp4 (ca.233 Mb)
15:20 – 16:20
Mogens Jensen (Niels Bohr
Abstract : Oscillating genetic patterns have been observed in networks related to the transcription factors NFkB,
p53 and Hes1 . We have identified the central feed-back loops leading to oscillations. By applying an external
periodic signal, it is possible to lock the internal oscillation to the external signal. For the NF-kB systems in single cells
we have observed that the two signals lock when the ration between the two frequencies is close to basic rational numbers .
resulting response of the cell can be mapped out as
dynamics of the concentration in NF-kB [2,3]. The
group of Savas Tay (ETH,
of the NF-kB system observed transitions from one tongue to the other when they overlap.
We investigate this effect by Gillespie simulations and find interesting time correlation for the transitions probabilities when
switching from one tongue to the other.
 B. Mengel, A. Hunziker, L. Pedersen, A. Trusina, M.H. Jensen and S. Krishna, "Modeling oscillatory control in NF-kB, p53
and Wnt signaling", Current Opinion in Genetics and Development 20, 656-664 (2010).
FEBS Letters 586, 1664-1668 (2012).
 N. Mitarai, U. Alon and M.H. Jensen, "Entrainment of linear and non-linear systems under noise",
Chaos, Chaos 23, 023125 (2013).
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