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“Optical manipulation and
bio-applications of plasmonic nanoparticles
“
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Date: |
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Time: |
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Thursday, 14. April 2016 |
Audio-only-Recording as MP3-File (smallest
possible size):
- Audio.mp3 (ca.27 Mb) ============================================ Video-Recording for any system with MP4-support:
- Video.mp4 (ca.252 Mb) |
15:15 – 16:15 |
Speaker :
Lene B. Oddershede (Niels Bohr Institutet)
Abstract :
A tightly
focused laser beam can trap and manipulate individual metallic nanoparticles both in liquid [1] and in air [2]. Not only
the position, but also the orientation of a single nanoparticle
can be controlled and such precise optical control of metallic nanoparticles has huge potential, e.g., for aerotaxy or nano-architectural
purposes. Due to their plasmonic properties, metallic
nanoparticles will absorb part of the incident light
and the energy will be released as heat into their local surroundings. The
heating associated with resonant irradiation of metallic nanoparticles
can be extreme. Moreover, this heating of an irradiated nanoparticle
cannot be theoretically predicted, as the precise focal intensity distribution
on the nanoscale is unknown and typically highly aberrated [3]. We developed a novel membrane-based assay to
directly quantify the temperature profile of an individual irradiated metallic nanoparticle and show how the temperature depends on laser
power and particle size, shape, orientation and composition [4,5]. Laser induced heating of metallic nanoparticles
can be advantageously used in a controlled manner, for instance to fuse
membranes and cargos of two selected giant unilamellar
vesicles [6]. Another promising application of these hot metallic nanoparticles is within cancer therapy, where novel results
show that laser irradiated metallic nanoparticles can
be used to mediate targeted drug delivery and for photothermal
tumor treatment.
[1] Hansen
et al., Expanding the optical trapping range of gold nanoparticles,
Nano Letters, vol. 5 p.1937-1942 (2005).
[2] Jauffred, Taheri, Schmitt, Linke, Oddershede. Optical Trapping of Gold Nanoparticles in
Air. Nano Letters, vol. 15 p. 4713-4719
(2015).
[3] Kyrsting et al., Mapping 3D focal intensity exposes the
stable trapping positions of single nanoparticles. Nano Letters vol.13 p.31-35
(2013).
[4] Bendix et al., Direct measurements of heating by
electromagnetically trapped gold nanoparticles on
supported lipid bilayers, ACS Nano,
vol. 4 p.2256-2262 (2010).
[5] Ma et
al., Heat generation by irradiated complex composite nanostructures. Nano Letters, vol. 14 p.612-619 (2014).
[6] A. Roervig-Lund, Bahadori, Semsey, Bendix, Oddershede. Vesicle fusion triggered by
optically heated gold nanoparticles, Nano Letters, vol. 15 p. 4183-4188 (2015).