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“Active Force Patterning as an Organizing Principle in Living Cells”

Date:

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Time:

Thursday, 01 Dec. 2022

Video-Recording for any system with MP4-support

- Video.mp4 (ca. 437 Mb)

15:15 – 16:25

Madan Rao

(Tata Institute for fundamental research)

Abstract:

The cell is a living state of matter with a definite internal organization

across multiple scales.

Typically, cells have a cytoskeleton, a structure that helps cells maintain

their shape and internal organization, and it also provides

mechanical support that enables cells to carry out essential functions

like division and movement. There is no single cytoskeletal component.

Rather, several different components work together to form the cytoskeleton.

Acto-myosin, a major component of the cell spanning cytoskeleton,

are the molecular correlates of biological force,

and their patterning controls this intracellular organization.

The key idea is that the cytoskeleton is not in thermal equilibrium,

it uses ATP (adenosyn tri-phosphate) to generate motion. It is active.

Using an active hydrodynamics description, we will discuss how novel

nonequilibrium features such as nonreciprocity of these actomyosin

derived forces give rise to force patterning in living cells.